The uses of cardiovascular risk estimationStrokes, heart attacks and peripheral arterial disease - cardiovascular risk is about common and important ill health outcomes. Any moves you make to reduce this risk, will have lots of more immediate benefits, however. If you are seeking advice on your personal cvs risk, it is worth understanding about relative and absolute risk reduction. If you have a very small risk of something happening, even a 50% (relative) reduction in that risk is not very important. The absolute risk reduction will also be very small. The National Heart Foundation of New Zealand has published an absolute risk calculator which is quick and easy to use... The chart uses total chloesterol / HDL ratio, as this is a much better predictor of coronary artery disease risk than is the total cholesterol alone. Always make sure that a HDL is done whenever your cholesterol is measured.
The NNT is 16. Total expected events untreated are 3, so the figures are as seen. Another person might say that taking drugs for 5 years, with the risks and doctor visits entailed, all for one chance of benefit in 16, would not interest them. I do point out as I present the figures, that the two episodes of illness may not have been as severe, and that the other 13 people may have not developed arterial disease as much, reducing future risk. The benefits of various medications are commonly quoted as percentage relative risk reductions. These don't mean much without the above type of information.
Homocysteine should be included in cardiovascular risk testsThis substance is a partial breakdown product of methionine, one of the building blocks of our proteins.The breakdown cannot be completed nor reversed, because of lack of one of four substances needed for these jobs. The four factors are vitamins B6, 9 and 12 and betaine. Homocysteine has the same history in medicine as cholesterol. Families were found who had very high levels due to genetic mutations, and very increased cardiovascular risk. Increased homocysteine levels are associated with 10% of the variance in risk between middle aged males. Cholesterol accounts for a smaller proportion Correcting the appropriate deficiency often relieves symptoms such as fatigue, balance problems and sleep disturbance. It is definitely not a case of pie in the sky...
Full versions of cardiovascular risk calculatorsThis first one uses imperial units, as in USACoronary Heart Disease Framingham Point Scores
This one uses SI units as in Australia Full copy of New Zealand risk calculator
Waist-hip ratio and intra-abdominal obesityThe MacArthur Successful Aging Study, a longitudinal study of high-functioning men and women, average age 74, was recently reported (in the October '09 issue of the Annals of Epidemiology.)Waist-hip ratio was found to predict all-cause mortality in these older adults. Whether over eating and under exercising are purely habits or due to our belief systems or emotional stuff, this whole scenario often offers the greatest possibilities for useful change in our lives. You can feel better as well as living longer, which is really more to the point. If you're in the mood for radical change, look at Leslie Kenton's book
"The New Raw Energy."
Latest on diagnosis of diabetes from American Diabetes AssociationRevised recommendations for diabetes diagnosis - hemoglobin A1c (HbA1c) is an easier diagnostic test, not requiring the 12 hours water only and two hours waiting needed for the OGGT used now.The new recommendations are published December 29 in the January supplement of Diabetes Care. They believe that use of the HbA1c will encourage more people to get tested for type 2 diabetes and help further reduce the number of people who are unaware of this cardiovascular risk factor. Type 2 diabetes actually can be prevented, as long as lifestyle changes are made while blood glucose levels are still in the pre-diabetes range."
Peridontal gum disease and cardiovascular riskA really hot topic in cardiology research is the "vulnerable plaque." Thin-cap fibroatheroma is thought to be more at risk of rupture and subsequent blood clot blocking the artery.Intravascular ultrasound is being used to find ruptured plaques in people with unstable angina. Why do plaques rupture or get surface erosion? This is one possible connection with peridontal disease, which is a known potent risk factor for heart attacks. Gum disease can increase a general tendency to inflammation throughout our body, and can lead to dissemination of germs via our blood stream. These can then damage plaques.
Treating gum disease to protect your heart
The spasm of resistance vessel (S-RV) conceptThe spasm of resistance vessels may directly induce symptoms in ischemic diseases.This is a credible theory1, and opens possibilities for treatment aimed at reducing the risk of spasm, such as magnesium supplements. Vagal withdrawal & Sympathetic activation, causing arrhythmiasReduced baroreflex sensitivity after heart attacks, and low heart rate variability, both indicating vagal underactivity, have been shown to be associated with substantially increased risk of subsequent sudden death.After recovery from ventricular fibrillation, people have markedly increased cardiac sympathetic activity. This dysfunction of the autonomic nerve control of the heart increases with age. Microembolism of vasa vasorum of coronary arteriesThe tiny blood vessels which supply nutrition to the walls of the coronary arteries themselves, have been shown to get blocked.This may be important in the development of plaque instability, or even the development of plaque in the first place. See3 http://www.thincs.org and http://www.ravnskov.nu/cholesterol.htm A2 milk - the way it used to be ( may have been better)A strong relationship has been found2 between the amount of A1 β-casein consumed and heart disease mortality.Apparently cows used to produce A2 beta casein, and still do in some areas of the world. The difference is only one amino acid, but it changes the way our body uses the milk. This genetic variant may have come from intensive dairy cattle breeding. A2 milk - another way to reduce your cardiovascular risk. Can infection cause heart disease?Chlamydia pneumoniae has been found in the fatty plaques from coronary arteries, and may help cause surface damage and instability.A very good discussion of this, from 2000, is at http://qjmed.oxfordjournals.org/cgi/content/full/93/6/375 References for cardiovascular risk1. Med Hypotheses. 1999 Sept 53(3):200-209.2. Ischaemic heart disease, Type 1 diabetes, and cow milk A1 beta casein. 3. "Vulnerable Plaque Formation from Obstruction of Vasa Vasorum by Homocysteinylated and Oxidized Lipoprotein Aggregates Complexed with Microbial Remnants and LDL Autoantibodies" From cardiovascular risk to home page
|
